Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation
نویسندگان
چکیده
منابع مشابه
Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation
Innate lymphoid cells (ILCs) represent innate versions of T helper and cytotoxic T cells that differentiate from committed ILC precursors (ILCPs). How ILCPs give rise to mature tissue-resident ILCs remains unclear. Here, we identify circulating and tissue ILCPs in humans that fail to express the transcription factors and cytokine outputs of mature ILCs but have these signature loci in an epigen...
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ژورنال
عنوان ژورنال: Cell
سال: 2017
ISSN: 0092-8674
DOI: 10.1016/j.cell.2017.02.021